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side effects in the treatment of pain: paracetamol

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side effects in the treatment of pain: paracetamol.



The pain is present in almost all diseases, so that the drugs used to alleviate it are widely used. Different studies point to these as one of the most used therapeutic subgroups and their consumption not to be increased year after year.

From the pharmacological standpoint, analgesics and antipyretics marketed in Spain have traditionally been classified into "acetylsalicylic acid derivatives," pyrazolones "," paracetamol and derivatives "and" other pain relievers and antipyretics. Of all the analgesics mentioned ( within this subgroup include NSAIDs including ibuprofen highlights to be discussed in an article from ), few are those who represent the largest share of consumption, in particular paracetamol and to a lesser extent, metamizol. Analgesic consumption has tripled between 1992 and 2006. This increase occurred at the expense of the use of paracetamol, which has risen from 50.9% of this subgroup in 1992 to over 75% in 2006.



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Paracetamol is indicated for the symptomatic relief of occasional mild to moderate pain such as headache, dental, muscular (contractures) or back pain (LBP) and as an antipyretic in febrile conditions.


When compared with other drugs for these indications, has a relatively good safety profile at normal doses which allowed adoption in many prescription medicines to the public that can be taken without medical supervision.


more adverse reactions have been reported during the period use of paracetamol hepatotoxicity, renal toxicity, abnormal blood count, hypoglycemia, and allergic dermatitis.


Paracetamol should not be taken for long periods of time nor in high doses, since even at therapeutic doses do not usually have toxic effects, both at very high doses and prolonged use continuous (usually after a year, but sometimes from week 3) can cause liver toxicity.

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